Reaction Details |
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Target | Nuclear receptor ROR-gamma |
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Ligand | BDBM368656 |
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Substrate/Competitor | n/a |
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IC50 | 2.10±n/a nM |
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Citation | Schnute, ME Methyl- and trifluoromethyl-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof US Patent US9920054 Publication Date 3/20/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma |
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Name: | Nuclear receptor ROR-gamma |
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58218.40 |
Organism: | Homo sapiens (Human) |
Description: | P51449 |
Residue: | 518 |
Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM368656 |
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n/a |
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Name | BDBM368656 |
Synonyms: | 3-cyano-N-(3-((1R,5S,8r)-3-isobutyryl-3- azabicyclo[3.2.1]octan-8-yl)-1-methyl-4- (trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-4- methoxybenzamide. | US10227346, Example 78 | US10426135, Example 78 | US9920054, Example 78 |
Type | Small organic molecule |
Emp. Form. | C29H30F3N5O3 |
Mol. Mass. | 553.5754 |
SMILES | COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc(C3[C@H]4CC[C@@H]3CN(C4)C(=O)C(C)C)c2c1C(F)(F)F |r| |
Structure |
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