Reaction Details |
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Target | Calpain-1 catalytic subunit |
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Ligand | BDBM23859 |
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Substrate/Competitor | BDBM23856 |
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Meas. Tech. | mu-Calpain Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 41±7 nM |
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Citation | Donkor, IO; Assefa, H; Liu, J Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids. J Med Chem51:4346-50 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Calpain-1 catalytic subunit |
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Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
Mol. Mass.: | 81729.82 |
Organism: | Sus scrofa (pig) |
Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
Residue: | 714 |
Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM23859 |
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BDBM23856 |
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Name | BDBM23859 |
Synonyms: | 3-[(2S)-2-[1-(adamantan-1-yl)acetamido]-4-methylpentanamido]-2-oxo-4-phenylbutanoic acid | Peptidyl alpha-Ketoacid, 2b |
Type | Small organic molecule |
Emp. Form. | C28H38N2O5 |
Mol. Mass. | 482.6117 |
SMILES | CC(C)C[C@H](NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)NC(Cc1ccccc1)C(=O)C(O)=O |r,TLB:16:11:18:15.14.17,16:15:11.12.10:18,THB:14:13:10:15.16.17,14:15:10:13.12.18| |
Structure |
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