| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM23864 |
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| Substrate/Competitor | BDBM23856 |
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| Meas. Tech. | mu-Calpain Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 1200±15 nM |
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| Citation |  Donkor, IO; Assefa, H; Liu, J Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids. J Med Chem51:4346-50 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
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| Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
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| Mol. Mass.: | 81729.82 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
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| Residue: | 714 |
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| Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM23864 |
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| BDBM23856 |
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| Name | BDBM23864 |
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| Synonyms: | Peptidyl alpha-Ketoester, 1e | methyl 3-[(2S)-2-[1-(9H-fluoren-9-yl)acetamido]-4-methylpentanamido]-2-oxo-4-phenylbutanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C32H34N2O5 |
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| Mol. Mass. | 526.6228 |
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| SMILES | COC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CC1c2ccccc2-c2ccccc12 |r| |
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| Structure | 
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