| Reaction Details |
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 | Report a problem with these data |
| Target | ALK tyrosine kinase receptor [L1196M] |
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| Ligand | BDBM261636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ELISA-Based in vitro Kinase Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 300±n/a nM |
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| Comments | extracted |
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| Citation |  Gambacorti-Passerini, C; Mologni, L; Scapozza, L; Bisson, W; Goekjian, P; D Attoma, J 2-acylaminothiazoles for the treatment of cancer US Patent US9708279 Publication Date 7/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| ALK tyrosine kinase receptor [L1196M] |
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| Name: | ALK tyrosine kinase receptor [L1196M] |
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| Synonyms: | ALK | ALK L1196M | ALK tyrosine kinase receptor (ALK) (L1196M) | ALK tyrosine kinase receptor (ALK)(L1196M) | ALK tyrosine kinase receptor (L1196M) | ALK_HUMAN | Anaplastic lymphoma kinase L1196M (ALK L1196M) | Tyrosine-protein kinase receptor [L1196M] |
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| Type: | n/a |
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| Mol. Mass.: | 176471.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UM73[L1196M] |
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| Residue: | 1620 |
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| Sequence: | MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVV
PSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEA
RTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQ
GEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDY
FTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQ
MDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGR
YIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFF
ALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYC
NFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFP
APIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPL
LDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNP
NKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPL
KGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGE
DACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLII
AAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGA
TGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFIS
PLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVS
CIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKL
SKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPN
DPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILMELMA
GGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCP
GPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIIL
ERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAA
PPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPT
SLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPS
SLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQPGP
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| BDBM261636 |
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| n/a |
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| Name | BDBM261636 |
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| Synonyms: | N-(4-(3,4-bis((2-(trifluoromethyl)phenyl)ethynyl)phenyl)thiazol-2-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide | US9708279, 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C40H30F6N4OS |
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| Mol. Mass. | 728.748 |
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| SMILES | CN1CCN(Cc2ccc(cc2)C(=O)Nc2nc(cs2)-c2ccc(C#Cc3ccccc3C(F)(F)F)c(c2)C#Cc2ccccc2C(F)(F)F)CC1 |
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| Structure | 
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