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TargetHistone-lysine N-methyltransferase SMYD3
LigandBDBM378446
Substrate/Competitorn/a
Meas. Tech.SMYD3 Biochemical Assay
IC50 0.810±n/a nM
Citation Foley, MAKuntz, KWMills, JEMitchell, LHMunchhof, MJHarvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent US10266526 Publication Date 4/23/2019
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase SMYD3
Name:Histone-lysine N-methyltransferase SMYD3
Synonyms:SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:Enzyme
Mol. Mass.:49101.22
Organism:Homo sapiens (Human)
Description:Q9H7B4-2
Residue:428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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  Blast E-value cutoff:
BDBM378446
n/a
NameBDBM378446
Synonyms:N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-6-chloro-2-oxoindoline-5-carboxamide | US10266526, Compound 579
TypeSmall organic molecule
Emp. Form.C21H28ClN5O4S
Mol. Mass.481.996
SMILESNC1CCN(CC1)S(=O)(=O)N1[C@H]2CC[C@@H]1C[C@@H](C2)NC(=O)c1cc2CC(=O)Nc2cc1Cl |r,TLB:7:10:13.12:17.16.15|
Structure
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