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TargetHistone-lysine N-methyltransferase SMYD3
LigandBDBM378452
Substrate/Competitorn/a
Meas. Tech.SMYD3 Biochemical Assay
IC50 1.73±n/a nM
Citation Foley, MAKuntz, KWMills, JEMitchell, LHMunchhof, MJHarvey, DM Substituted 1,2,3-triazoles as SMYD inhibitors for treating cancer US Patent US10266526 Publication Date 4/23/2019
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase SMYD3
Name:Histone-lysine N-methyltransferase SMYD3
Synonyms:SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:Enzyme
Mol. Mass.:49101.22
Organism:Homo sapiens (Human)
Description:Q9H7B4-2
Residue:428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM
RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES
EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL
DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW
KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE
CDANIRAS
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  Blast E-value cutoff:
BDBM378452
n/a
NameBDBM378452
Synonyms:6-chloro-N-((1R,3r,5S)-8-(((1-(3-hydroxypropyl)piperidin-4-yl)methyl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-oxoindoline-5-carboxamide | US10266526, Compound 585
TypeSmall organic molecule
Emp. Form.C25H35ClN4O5S
Mol. Mass.539.087
SMILESOCCCN1CCC(CS(=O)(=O)N2[C@H]3CC[C@@H]2C[C@@H](C3)NC(=O)c2cc3CC(=O)Nc3cc2Cl)CC1 |r,TLB:9:12:15.14:19.18.17|
Structure
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