| Reaction Details |
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 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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| Ligand | BDBM24078 |
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| Substrate/Competitor | BDBM2 |
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| Meas. Tech. | Kinesin ATPase In Vitro Assay |
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| pH | 7±n/a |
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| Temperature | 296.15±n/a K |
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| IC50 | 119±n/a nM |
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| Citation |  Cox, CD; Torrent, M; Breslin, MJ; Mariano, BJ; Whitman, DB; Coleman, PJ; Buser, CA; Walsh, ES; Hamilton, K; Schaber, MD; Lobell, RB; Tao, W; South, VJ; Kohl, NE; Yan, Y; Kuo, LC; Prueksaritanont, T; Slaughter, DE; Li, C; Mahan, E; Lu, B; Hartman, GD Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett16:3175-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
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| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 101769.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UNA0 |
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| Residue: | 930 |
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| Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
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| BDBM24078 |
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| BDBM2 |
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| Name | BDBM24078 |
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| Synonyms: | 3,5-diaryl-4,5-dihydropyrazole, 9c | 5-(4-{2-azabicyclo[2.2.1]hept-5-en-2-yl}butyl)-3-(2,5-difluorophenyl)-N-ethyl-5-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H32F2N4O |
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| Mol. Mass. | 478.5767 |
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| SMILES | CCNC(=O)N1N=C(CC1(CCCCN1CC2CC1C=C2)c1ccccc1)c1cc(F)ccc1F |c:6,21| |
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| Structure | 
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