| Reaction Details |
|---|
 | Report a problem with these data |
| Target | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Ligand | BDBM24095 |
|---|
| Substrate/Competitor | BDBM2 |
|---|
| Meas. Tech. | Kinesin ATPase In Vitro Assay |
|---|
| pH | 7±n/a |
|---|
| Temperature | 296.15±n/a K |
|---|
| IC50 | 3.8±n/a nM |
|---|
| Citation |  Roecker, AJ; Coleman, PJ; Mercer, SP; Schreier, JD; Buser, CA; Walsh, ES; Hamilton, K; Lobell, RB; Tao, W; Diehl, RE; South, VJ; Davide, JP; Kohl, NE; Yan, Y; Kuo, LC; Li, C; Fernandez-Metzler, C; Mahan, EA; Prueksaritanont, T; Hartman, GD Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett17:5677-82 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 101769.09 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UNA0 |
|---|
| Residue: | 930 |
|---|
| Sequence: | MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
|
|
|
|---|
| BDBM24095 |
|---|
| BDBM2 |
|---|
| Name | BDBM24095 |
|---|
| Synonyms: | 1,4-diaryl-4,5-dihydropyrazole, 15 | 1-[1-(2,5-difluorophenyl)-4-phenyl-4-[3-(pyrrolidin-1-yl)propyl]-4,5-dihydro-1H-pyrazol-3-yl]ethan-1-one | Racemate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H27F2N3O |
|---|
| Mol. Mass. | 411.4875 |
|---|
| SMILES | CC(=O)C1=NN(CC1(CCCN1CCCC1)c1ccccc1)c1cc(F)ccc1F |t:3| |
|---|
| Structure | 
|
|---|
Search and Browse
