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TargetA disintegrin and metalloproteinase with thrombospondin motifs 5
LigandBDBM24101
Substrate/CompetitorBDBM2
Meas. Tech.Kinesin ATPase In Vitro Assay
pH7±n/a
Temperature296.15±n/a K
IC50 10.1±n/a nM
Citation Roecker, AJColeman, PJMercer, SPSchreier, JDBuser, CAWalsh, ESHamilton, KLobell, RBTao, WDiehl, RESouth, VJDavide, JPKohl, NEYan, YKuo, LCLi, CFernandez-Metzler, CMahan, EAPrueksaritanont, THartman, GD Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett17:5677-82 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
A disintegrin and metalloproteinase with thrombospondin motifs 5
Name:A disintegrin and metalloproteinase with thrombospondin motifs 5
Synonyms:A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) | ADAMTS11 | ADAMTS5 | ADMP2 | ATS5_HUMAN | Aggrecanase-2 | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)
Type:Enzyme
Mol. Mass.:101769.09
Organism:Homo sapiens (Human)
Description:Q9UNA0
Residue:930
Sequence:
MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM24101
BDBM2
NameBDBM24101
Synonyms:1,4-diaryl-4,5-dihydropyrazole, 21 | 1-{4-[3-(4-acetylpiperazin-1-yl)propyl]-1-[2-fluoro-5-(trifluoromethyl)phenyl]-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl}ethan-1-one | Racemate
TypeSmall organic molecule
Emp. Form.C27H30F4N4O2
Mol. Mass.518.5463
SMILESCC(=O)N1CCN(CCCC2(CN(N=C2C(C)=O)c2cc(ccc2F)C(F)(F)F)c2ccccc2)CC1 |c:13|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: