| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM261740 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | M1 PAM Assay |
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| EC50 | 345±n/a nM |
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| Citation |  Groebke Zbinden, K; Pinard, E; Ryckmans, T Flouro-naphthyl derivatives US Patent US9708302 Publication Date 7/18/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51390.46 |
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| Organism: | RAT |
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| Description: | P08482 |
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| Residue: | 460 |
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| Sequence: | MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM261740 |
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| n/a |
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| Name | BDBM261740 |
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| Synonyms: | 4-((4-Cyano-4-(pyridin-2-yl)piperidin-1-yl)methyl)-1-fluoro-N-((1S,2S)-2-hydroxycyclohexyl)-2-naphthamide | US9708302, 26 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H31FN4O2 |
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| Mol. Mass. | 486.5804 |
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| SMILES | O[C@H]1CCCC[C@@H]1NC(=O)c1cc(CN2CCC(CC2)(C#N)c2ccccn2)c2ccccc2c1F |r| |
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| Structure | 
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