| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 |
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| Ligand | BDBM24151 |
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| Substrate/Competitor | BDBM2 |
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| Meas. Tech. | Microtubule-Stimulated KSP ATPase Activity Assay |
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| pH | 7±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 9900±2100 nM |
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| Citation |  Pinkerton, AB; Lee, TT; Hoffman, TZ; Wang, Y; Kahraman, M; Cook, TG; Severance, D; Gahman, TC; Noble, SA; Shiau, AK; Davis, RL Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors. Bioorg Med Chem Lett17:3562-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Kinesin-like protein KIF11 |
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| Name: | Kinesin-like protein KIF11 |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119138.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457426 |
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| Residue: | 1056 |
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| Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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| BDBM24151 |
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| BDBM2 |
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| Name | BDBM24151 |
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| Synonyms: | N-[3-(diethylcarbamoyl)-4H,5H,6H-cyclopenta[b]thiophen-2-yl]thiophene-2-carboxamide | thiophene containing compound, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N2O2S2 |
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| Mol. Mass. | 348.483 |
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| SMILES | CCN(CC)C(=O)c1c(NC(=O)c2cccs2)sc2CCCc12 |
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| Structure | 
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