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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase HCK | ||
| Ligand | BDBM378885 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Inhibition Assays | ||
| IC50 | 3.00±n/a nM | ||
| Citation |  Yang, S; Wei, Y 3-acetylenyl-pyrazole-pyrimidine derivative, and preparation method therefor and uses thereof US Patent US10266537 Publication Date 4/23/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase HCK | |||
| Name: | Tyrosine-protein kinase HCK | ||
| Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 59600.18 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08631 | ||
| Residue: | 526 | ||
| Sequence: |
| ||
| BDBM378885 | |||
| n/a | |||
| Name | BDBM378885 | ||
| Synonyms: | US10266537, Compound 93 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H27F3N6O2 | ||
| Mol. Mass. | 548.5589 | ||
| SMILES | Cc1ccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 |r,wU:26.27,wD:29.31,(-5.46,5.4,;-3.98,5.8,;-3.58,7.29,;-2.09,7.69,;-1,6.6,;.49,7,;1.57,5.91,;1.18,4.42,;3.06,6.31,;3.46,7.79,;4.95,8.19,;6.04,7.1,;7.53,7.5,;5.64,5.62,;4.15,5.22,;6.73,4.53,;8.22,4.93,;6.33,3.04,;7.82,3.44,;-1.4,5.11,;-2.89,4.71,;-3.29,3.22,;-3.68,1.74,;-4.08,.25,;-3.18,-1,;-4.08,-2.24,;-3.68,-3.73,;-2.2,-4.13,;-1.8,-5.62,;-2.89,-6.7,;-2.49,-8.19,;-4.38,-6.31,;-4.77,-4.82,;-5.55,-1.77,;-6.88,-2.54,;-8.22,-1.77,;-8.22,-.23,;-6.88,.54,;-6.88,2.08,;-5.55,-.23,)| | ||
| Structure | 
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