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TargetMitotic checkpoint serine/threonine-protein kinase BUB1
LigandBDBM378932
Substrate/Competitorn/a
Meas. Tech.Bub1 Kinase Assay
IC50 2.60±n/a nM
Citation Hitchcock, MMengel, APütter, VSiemeister, GWengner, AMBriem, HEis, KSchulze, VFernandez-Montalvan, AEPrechtl, SHolton, SFanghänel, JLienau, PPreusse, CGnoth, MJ Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases US Patent US10266548 Publication Date 4/23/2019
More Info.:Get all data from this article,  Assay Method
 
Mitotic checkpoint serine/threonine-protein kinase BUB1
Name:Mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms:BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1
Type:PROTEIN
Mol. Mass.:122372.31
Organism:Homo sapiens (Human)
Description:ChEMBL_1510603
Residue:1085
Sequence:
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM378932
n/a
NameBDBM378932
Synonyms:2-[1-(6-chloro-2- fluoro-3- methoxybenzyl)- 1H-indazol-3-yl]- 5-methoxy-N- (pyridin-4- yl)pyrimidin-4- amine | US10266548, Example 2-2-1
TypeSmall organic molecule
Emp. Form.C25H20F2N6O2
Mol. Mass.474.4621
SMILESCOc1ccc(F)c(Cn2nc(-c3ncc(OC)c(Nc4ccncc4)n3)c3ccccc23)c1F
Structure
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