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TargetMitotic checkpoint serine/threonine-protein kinase BUB1
LigandBDBM379041
Substrate/Competitorn/a
Meas. Tech.Bub1 Kinase Assay
IC50 4.80±n/a nM
Citation Hitchcock MMengel APütter VSiemeister GWengner AMBriem HEis KSchulze VFernandez-Montalvan AEPrechtl SHolton SFanghänel JLienau PPreusse CGnoth MJ Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases US Patent  US10266548 Publication Date 4/23/2019  Article
More Info.:Get all data from this article,  Assay Method
 
Mitotic checkpoint serine/threonine-protein kinase BUB1
Name:Mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms:BUB1A | hBUB1
Type:PROTEIN
Mol. Mass.:122372.31
Organism:Homo sapiens (Human)
Description:ChEMBL_1510603
Residue:1085
Sequence:
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM379041
n/a
NameBDBM379041
Synonyms:(2S)-3-({2-[1-(2- fluorobenzyl)- 1H-indazol-3-yl]- 4-(pyridin-4- ylamino) pyrimidin- 5- yl}oxy)propane- 1,2-diol | US10266548, Example 12-3 | US10266548, Example 15-2
TypeSmall organic molecule
Emp. Form.C26H23FN6O3
Mol. Mass.486.4976
SMILESOC[C@H](O)COc1cnc(nc1Nc1ccncc1)-c1nn(Cc2ccccc2F)c2ccccc12 |r|
Structure
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