Ki Summary

Reaction Details

Report a problem with these data

Target

Dihydroorotate dehydrogenase (quinone), mitochondrial

Ligand

BDBM24410

Substrate/Competitor

BDBM15346

Meas. Tech.

DHODH Inhibition Assay

8±n/a

Temperature

293.15±n/a K

IC50

2000±70 nM

Citation

Phillips, MA; Gujjar, R; Malmquist, NA; White, J; El Mazouni, F; Baldwin, J; Rathod, PK Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. J Med Chem51:3649-53 (2008) [PubMed] Article

More Info.:

Get all data from this article, Inhibition_Run data, Solution Info, Assay Method

Dihydroorotate dehydrogenase (quinone), mitochondrial

Name:

Dihydroorotate dehydrogenase (quinone), mitochondrial

Synonyms:

DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7

Type:

Enzyme

Mol. Mass.:

65581.88

Organism:

Plasmodium falciparum (isolate 3D7)

Description:

Q08210

Residue:

569

Sequence:

MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS

BDBM24410

BDBM15346

Name

BDBM24410

Synonyms:

2-methyl-7-({5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}amino)-4H-chromen-4-one | Triazolopyrimidine-Based Compound, 17

Type

Small organic molecule

Emp. Form.

C16H13N5O2

Mol. Mass.

307.3067

SMILES

Cc1cc(Nc2ccc3c(c2)oc(C)cc3=O)n2ncnc2n1

Structure