Ki Summary

Reaction Details

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Target

Histone deacetylase 11

Ligand

BDBM24624

Substrate/Competitor

BDBM19411

Meas. Tech.

HDAC Enzyme Inhibition Assay

8±n/a

Temperature

310.15±n/a K

IC50

590±230 nM

Citation

Zhou, N; Moradei, O; Raeppel, S; Leit, S; Frechette, S; Gaudette, F; Paquin, I; Bernstein, N; Bouchain, G; Vaisburg, A; Jin, Z; Gillespie, J; Wang, J; Fournel, M; Yan, PT; Trachy-Bourget, MC; Kalita, A; Lu, A; Rahil, J; MacLeod, AR; Li, Z; Besterman, JM; Delorme, D Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor. J Med Chem51:4072-5 (2008) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Histone deacetylase 11

Name:

Histone deacetylase 11

Synonyms:

HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11

Type:

Chromatin regulator; hydrolase; repressor

Mol. Mass.:

39187.66

Organism:

Homo sapiens (Human)

Description:

Q96DB2

Residue:

347

Sequence:

MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP

BDBM24624

BDBM19411

Name

BDBM24624

Synonyms:

CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminophenyl)-4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzamide | US10227295, Compound MGCD0103 | US11377423, MGCD-0103 | US9409858, MGCD0103 | US9751832, MGCD0103 | US9956192, Compound MGCD0103

Type

Small organic molecule

Emp. Form.

C23H20N6O

Mol. Mass.

396.4445

SMILES

Nc1ccccc1NC(=O)c1ccc(CNc2nccc(n2)-c2cccnc2)cc1

Structure