| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM24666 |
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| Substrate/Competitor | BDBM21974 |
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| Meas. Tech. | Enzyme Inhibition and Ki Determination |
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| pH | 6.5±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | 4800±n/a nM |
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| IC50 | 7700±n/a nM |
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| Citation |  Kumar, S; Jaller, D; Patel, B; LaLonde, JM; DuHadaway, JB; Malachowski, WP; Prendergast, GC; Muller, AJ Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem51:4968-77 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM24666 |
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| BDBM21974 |
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| Name | BDBM24666 |
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| Synonyms: | 4-(1H-imidazol-4-yl)benzene-1-thiol | 4-(1H-imidazol-4-yl)benzenethiol, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H8N2S |
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| Mol. Mass. | 176.238 |
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| SMILES | Sc1ccc(cc1)-c1c[nH]cn1 |
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| Structure | 
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