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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM24666
Substrate/CompetitorBDBM21974
Meas. Tech.Enzyme Inhibition and Ki Determination
pH6.5±n/a
Temperature310.15±n/a K
Ki 4800±n/a nM
IC50 7700±n/a nM
Citation Kumar SJaller DPatel BLaLonde JMDuHadaway JBMalachowski WPPrendergast GCMuller AJ Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. J Med Chem 51:4968-77 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM24666
BDBM21974
NameBDBM24666
Synonyms:4-(1H-imidazol-4-yl)benzene-1-thiol | 4-(1H-imidazol-4-yl)benzenethiol, 18
TypeSmall organic molecule
Emp. Form.C9H8N2S
Mol. Mass.176.238
SMILESSc1ccc(cc1)-c1c[nH]cn1
Structure
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