Reaction Details |
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Target | Indoleamine 2,3-dioxygenase 1 |
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Ligand | BDBM24782 |
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Substrate/Competitor | BDBM21974 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 6.5±n/a |
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Temperature | 310.15±n/a K |
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Comments | No activity. |
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Citation | Kumar, S; Malachowski, WP; DuHadaway, JB; LaLonde, JM; Carroll, PJ; Jaller, D; Metz, R; Prendergast, GC; Muller, AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem51:1706-18 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Indoleamine 2,3-dioxygenase 1 |
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Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM24782 |
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BDBM21974 |
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Name | BDBM24782 |
Synonyms: | 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione | Phylloquinone | Phytonadione | vitamin K1, 11 |
Type | vitamin |
Emp. Form. | C31H46O2 |
Mol. Mass. | 450.6957 |
SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCCC(C)=CCC1=C(C)C(=O)c2ccccc2C1=O |w:18.18,c:20| |
Structure |
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