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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM24785
Substrate/CompetitorBDBM21974
Meas. Tech.Enzyme Inhibition Assay
pH6.5±n/a
Temperature310.15±n/a K
IC50 340±n/a nM
Citation Kumar SMalachowski WPDuHadaway JBLaLonde JMCarroll PJJaller DMetz RPrendergast GCMuller AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem 51:1706-18 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM24785
BDBM21974
NameBDBM24785
Synonyms:(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(1,4-dihydroxy-3-methylnaphthalen-2-yl)sulfanyl]ethyl]carbamoyl}butanoic acid | Hydroquinone derivative, 14
TypeSmall organic molecule
Emp. Form.C21H25N3O8S
Mol. Mass.479.504
SMILESCc1c(O)c2ccccc2c(O)c1SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O |r|
Structure
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