| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
|---|
| Ligand | BDBM24785 |
|---|
| Substrate/Competitor | BDBM21974 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| pH | 6.5±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 340±n/a nM |
|---|
| Citation |  Kumar, S; Malachowski, WP; DuHadaway, JB; LaLonde, JM; Carroll, PJ; Jaller, D; Metz, R; Prendergast, GC; Muller, AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem51:1706-18 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Indoleamine 2,3-dioxygenase 1 |
|---|
| Name: | Indoleamine 2,3-dioxygenase 1 |
|---|
| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45330.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14902 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
|
|
|
|---|
| BDBM24785 |
|---|
| BDBM21974 |
|---|
| Name | BDBM24785 |
|---|
| Synonyms: | (2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-[(1,4-dihydroxy-3-methylnaphthalen-2-yl)sulfanyl]ethyl]carbamoyl}butanoic acid | Hydroquinone derivative, 14 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25N3O8S |
|---|
| Mol. Mass. | 479.504 |
|---|
| SMILES | Cc1c(O)c2ccccc2c(O)c1SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
