Reaction Details |
| Report a problem with these data |
Target | Indoleamine 2,3-dioxygenase 1 |
---|
Ligand | BDBM24809 |
---|
Substrate/Competitor | BDBM21974 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
IC50 | 2120±n/a nM |
---|
Citation | Kumar, S; Malachowski, WP; DuHadaway, JB; LaLonde, JM; Carroll, PJ; Jaller, D; Metz, R; Prendergast, GC; Muller, AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem51:1706-18 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Indoleamine 2,3-dioxygenase 1 |
---|
Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
|
|
|
BDBM24809 |
---|
BDBM21974 |
---|
Name | BDBM24809 |
Synonyms: | (3S,4S)-4-(benzylsulfanyl)-3-hydroxy-2,2-dimethyl-2H,3H,4H,5H,10H-naphtho[2,3-b]pyran-5,10-dione | Pyranonaphthoquinone derivative, 48 |
Type | Small organic molecule |
Emp. Form. | C22H20O4S |
Mol. Mass. | 380.457 |
SMILES | CC1(C)OC2=C([C@H](SCc3ccccc3)[C@H]1O)C(=O)c1ccccc1C2=O |r,c:4| |
Structure |
|