| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
|---|
| Ligand | BDBM24811 |
|---|
| Substrate/Competitor | BDBM21974 |
|---|
| Meas. Tech. | Enzyme Inhibition Assay |
|---|
| IC50 | 512±n/a nM |
|---|
| Citation |  Kumar, S; Malachowski, WP; DuHadaway, JB; LaLonde, JM; Carroll, PJ; Jaller, D; Metz, R; Prendergast, GC; Muller, AJ Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors. J Med Chem51:1706-18 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Indoleamine 2,3-dioxygenase 1 |
|---|
| Name: | Indoleamine 2,3-dioxygenase 1 |
|---|
| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45330.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P14902 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
|
|
|
|---|
| BDBM24811 |
|---|
| BDBM21974 |
|---|
| Name | BDBM24811 |
|---|
| Synonyms: | (3S,4R)-3-bromo-4-hydroxy-2,2-dimethyl-2H,3H,4H,5H,10H-naphtho[2,3-b]pyran-5,10-dione | Pyranonaphthoquinone derivative, 52 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13BrO4 |
|---|
| Mol. Mass. | 337.165 |
|---|
| SMILES | CC1(C)OC2=C([C@@H](O)[C@@H]1Br)C(=O)c1ccccc1C2=O |r,c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
