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TargetIndoleamine 2,3-dioxygenase 1
LigandBDBM24817
Substrate/CompetitorBDBM21974
Meas. Tech.Enzyme Inhibition Assay
pH6.5±n/a
Temperature310.15±n/a K
Ki 42060±n/a nM
Citation Gaspari PBanerjee TMalachowski WPMuller AJPrendergast GCDuHadaway JBennett SDonovan AM Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem 49:684-92 (2006) [PubMed]  Article
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Indoleamine 2,3-dioxygenase 1
Name:Indoleamine 2,3-dioxygenase
Synonyms:IDO | IDO-1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine-pyrrole 2,3-dioxygenase
Type:Enzyme
Mol. Mass.:45330.80
Organism:Homo sapiens (Human)
Description:n/a
Residue:403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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  Blast E-value cutoff:
BDBM24817
BDBM21974
NameBDBM24817
Synonyms:Brassinin derivative, 5 | N-(2,3-dihydro-1H-inden-2-yl)(methylsulfanyl)carbothioamide
TypeSmall organic molecule
Emp. Form.C11H13NS2
Mol. Mass.223.358
SMILESCSC(=S)NC1Cc2ccccc2C1
Structure
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