Reaction Details | |||
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Target | Indoleamine 2,3-dioxygenase 1 | ||
Ligand | BDBM24818 | ||
Substrate/Competitor | BDBM21974 | ||
Meas. Tech. | Enzyme Inhibition Assay | ||
pH | 6.5±n/a | ||
Temperature | 310.15±n/a K | ||
Ki | 179600±n/a nM | ||
Citation | Gaspari, P; Banerjee, T; Malachowski, WP; Muller, AJ; Prendergast, GC; DuHadaway, J; Bennett, S; Donovan, AM Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem49:684-92 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Indoleamine 2,3-dioxygenase 1 | |||
Name: | Indoleamine 2,3-dioxygenase 1 | ||
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase | ||
Type: | Enzyme | ||
Mol. Mass.: | 45330.80 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P14902 | ||
Residue: | 403 | ||
Sequence: |
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BDBM24818 | |||
BDBM21974 | |||
Name | BDBM24818 | ||
Synonyms: | Brassinin derivative, 6 | N-(adamantan-2-yl)(methylsulfanyl)carbothioamide | ||
Type | Small organic molecule | ||
Emp. Form. | C12H19NS2 | ||
Mol. Mass. | 241.416 | ||
SMILES | CSC(=S)NC1C2CC3CC(C2)CC1C3 |TLB:4:5:8.7.14:10.11.12,14:13:9.8.7:11,THB:4:5:9.8.7:11,9:8:5:10.11.12,9:10:5:8.7.14,14:8:11:5.13.12,(2.8,2.34,;1.58,1.4,;.16,1.97,;-.06,3.5,;-1.06,1.02,;-2.48,1.6,;-2.8,.35,;-4.35,.27,;-6.36,1.56,;-7.42,.47,;-5.99,.53,;-3.89,-.74,;-5.45,2.65,;-4.01,3.05,;-6.03,2.85,)| | ||
Structure |