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TargetRAC-alpha serine/threonine-protein kinase
LigandBDBM24848
Substrate/CompetitorFluorescent-labeled Crosstide
Meas. Tech.Akt1 Kinase Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 3.1±1.9 nM
Citation Lippa, BPan, GCorbett, MLi, CKauffman, GSPandit, JRobinson, SWei, LKozina, EMarr, ESBorzillo, GKnauth, EBarbacci-Tobin, EGVincent, PTroutman, MBaker, DRajamohan, FKakar, SClark, TMorris, J Synthesis and structure based optimization of novel Akt inhibitors. Bioorg Med Chem Lett18:3359-63 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
RAC-alpha serine/threonine-protein kinase
Name:RAC-alpha serine/threonine-protein kinase
Synonyms:AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:Enzyme
Mol. Mass.:55681.25
Organism:Homo sapiens (Human)
Description:P31749
Residue:480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM24848
Fluorescent-labeled Crosstide
Name:Fluorescent-labeled Crosstide
Synonyms:5(6)-Carboxytetramethylrhodamine-labeled peptide | TAMRA-labeled peptide
Type:Fluorescent dye labeled peptide
Mol. Mass.:1165.24
Organism:n/a
Description:n/a
Residue:11
Sequence:
GRPRTSSFAEG