Ki Summary

Reaction Details

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Target

Fatty acid synthase [2202-2509]

Ligand

BDBM24986

Substrate/Competitor

BDBM24568

Meas. Tech.

Fluorogenic Assay for Detection of FASTE Inhibition

7.5±n/a

Temperature

310.15±n/a K

880±100 nM

Citation

Richardson, RD; Smith, JW Novel antagonists of the thioesterase domain of human fatty acid synthase. Mol Cancer Ther6:2120-6 (2007) [PubMed] Article

More Info.:

Get all data from this article, Inhibition_Run data, Solution Info, Assay Method

Fatty acid synthase [2202-2509]

Name:

Fatty acid synthase [2202-2509]

Synonyms:

FAS | FASN | FAS_HUMAN | Fatty Acid Synthase

Type:

Thioesterase domain

Mol. Mass.:

33927.11

Organism:

Homo sapiens (Human)

Description:

The recombinant thioesterase domain (residues 2202-2509) of FAS was cloned and expressed in Escheria coli. The thioesterase was purified by Ni-affinity chromatography, and analyzed for activity and inhibition by Orlistat.

Residue:

308

Sequence:

CPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLA
SRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQL
QAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHN
RVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHG
NVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSL
AEPRVSVR

BDBM24986

BDBM24568

Name

BDBM24986

Synonyms:

(5E)-1-(3-bromophenyl)-5-{[5-(2-nitrophenyl)furan-2-yl]methylidene}-1,3-diazinane-2,4,6-trione | 5-(furan-2-ylmethylene) pyrimidine-2,4,6-trione derivative, 3

Type

Small organic molecule

Emp. Form.

C21H12BrN3O6

Mol. Mass.

482.24

SMILES

[O-][N+](=O)c1ccccc1-c1ccc(C=C2C(=O)NC(=O)N(C2=O)c2cccc(Br)c2)o1 |w:13.13|

Structure