| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK2 |
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| Ligand | BDBM25116 |
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| Substrate/Competitor | Biotinylated PLKtide |
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| Meas. Tech. | PLK Kinase Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | >20000±n/a nM |
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| Km | 2000±n/a nM |
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| Citation |  Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity. Biochemistry46:9551-63 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Serine/threonine-protein kinase PLK2 |
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| Name: | Serine/threonine-protein kinase PLK2 |
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| Synonyms: | PLK2 | PLK2_HUMAN | Polo-Like Kinase 2 | SNK | Serine/threonine-protein kinase PLK2 | Serine/threonine-protein kinase SNK | Serum-inducible kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 78259.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PLK2 was expressed as GST-fusion protein using baculovirus expression system. GST-PLK2 was purified by using glutathione sepharose chromatography. |
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| Residue: | 685 |
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| Sequence: | MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH
HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEP
EVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTI
CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMP
SSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPA
KNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEEL
QPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLR
GCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPD
KKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRL
YLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRISTTFRLTTL
LMSGCSSELKNRMEYALNMLLQRCN
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| BDBM25116 |
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| Biotinylated PLKtide |
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| Name: | Biotinylated PLKtide |
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| Synonyms: | n/a |
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| Type: | Peptide |
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| Mol. Mass.: | 1447.52 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 13 |
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| Sequence: | |
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