Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM25147 |
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Substrate/Competitor | Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate |
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Meas. Tech. | HDAC Activity Assay |
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pH | 8±n/a |
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Temperature | 310.15±n/a K |
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IC50 | >10000±n/a nM |
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Citation | Jones, P; Altamura, S; De Francesco, R; Paz, OG; Kinzel, O; Mesiti, G; Monteagudo, E; Pescatore, G; Rowley, M; Verdirame, M; Steinkühler, C A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo. J Med Chem51:2350-3 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM25147 |
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Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate |
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Name: | Fluor de Lys-HDAC8 Fluorogenic Deacetylase Substrate |
Synonyms: | n/a |
Type: | fluorogenic, diacetylated peptide |
Mol. Mass.: | 1716.47 |
Organism: | n/a |
Description: | Residues 379-382 of p53. |
Residue: | 16 |
Sequence: | |