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TargetHistone deacetylase 4 [653-1084,H976Y]
LigandBDBM25161
Substrate/CompetitorBDBM25143
Meas. Tech.HDAC Activity Assay
Temperature298.15±n/a K
IC50 350±n/a nM
Commentsextracted
Citation Jones, PBottomley, MJCarfí, ACecchetti, OFerrigno, FLo Surdo, POntoria, JMRowley, MScarpelli, RSchultz-Fademrecht, CSteinkühler, C 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors. Bioorg Med Chem Lett18:3456-61 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Histone deacetylase 4 [653-1084,H976Y]
Name:Histone deacetylase 4 [653-1084,H976Y]
Synonyms:HDAC4 | HDAC4_HUMAN | Histone Deacetylase 4 (HDAC4) Mutant (H976Y) | Histone deacetylase 4 gain of function (GOF) mutant | KIAA0288
Type:Catalytic domain
Mol. Mass.:46476.72
Organism:Homo sapiens (Human)
Description:His-tagged HDAC4 GOF(gain of function, H976Y) catalytic domains (T653-L1084) was expressed in E.coli and purified by Nickel-Chelation affinity chromatography and anion exchange (MonoQ) chromatography.
Residue:432
Sequence:
TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQ
TVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAAR
LAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVS
KILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNM
AFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARC
FGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEACVSALLGNELDPLPEKVLQQRPNAN
AVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKR
PDEEPMEEEPPL
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  Blast E-value cutoff:
BDBM25161
BDBM25143
NameBDBM25161
Synonyms:N-(cyclohexylmethyl)-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | thiophene derivative, 3g
TypeSmall organic molecule
Emp. Form.C14H16F3NO2S
Mol. Mass.319.343
SMILESFC(F)(F)C(=O)c1ccc(s1)C(=O)NCC1CCCCC1
Structure
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