| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM25183 |
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| Substrate/Competitor | BDBM25143 |
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| Meas. Tech. | HDAC Activity Assay |
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| Temperature | 298.15±n/a K |
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| Comments | extracted |
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| Citation |  Jones, P; Bottomley, MJ; Carfí, A; Cecchetti, O; Ferrigno, F; Lo Surdo, P; Ontoria, JM; Rowley, M; Scarpelli, R; Schultz-Fademrecht, C; Steinkühler, C 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors. Bioorg Med Chem Lett18:3456-61 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM25183 |
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| BDBM25143 |
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| Name | BDBM25183 |
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| Synonyms: | N-(cyclohexylmethyl)-2-(2,2,2-trifluoroacetyl)-1,3-thiazole-5-carboxamide | thiazole derivative, 29g |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15F3N2O2S |
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| Mol. Mass. | 320.331 |
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| SMILES | FC(F)(F)C(=O)c1ncc(s1)C(=O)NCC1CCCCC1 |
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| Structure | 
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