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TargetGeranylgeranyl pyrophosphate synthase
LigandBDBM25256
Substrate/CompetitorBDBM25257
Meas. Tech.GGPP Synthase Inhibition Assay
pH7±n/a
Temperature310.15±n/a K
IC50 100±n/a nM
Citation K-M Chen, CHudock, MPZhang, YGuo, RTCao, RNo, JHLiang, PHKo, TPChang, THChang, SCSong, YAxelson, JKumar, AWang, AHOldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem51:5594-607 (2008) [PubMed]  Article
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Geranylgeranyl pyrophosphate synthase
Name:Geranylgeranyl pyrophosphate synthase
Synonyms:Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:Homooctamer; transferase
Mol. Mass.:34867.94
Organism:Homo sapiens (Human)
Description:Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM25256
BDBM25257
NameBDBM25256
Synonyms:bisphosphonate, 9 | hydrogen [2-(dodecyldimethylphosphanylium)-1-phosphonoethyl]phosphonate
TypeSmall organic molecule
Emp. Form.C16H37O6P3
Mol. Mass.418.3827
SMILESCCCCCCCCCCCC[P+](C)(C)CC(P(O)(O)=O)P(O)([O-])=O
Structure
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