Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM25256 |
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Substrate/Competitor | BDBM25257 |
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Meas. Tech. | GGPP Synthase Inhibition Assay |
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pH | 7±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 100±n/a nM |
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Citation | K-M Chen, C; Hudock, MP; Zhang, Y; Guo, RT; Cao, R; No, JH; Liang, PH; Ko, TP; Chang, TH; Chang, SC; Song, Y; Axelson, J; Kumar, A; Wang, AH; Oldfield, E Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem51:5594-607 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM25256 |
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BDBM25257 |
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Name | BDBM25256 |
Synonyms: | bisphosphonate, 9 | hydrogen [2-(dodecyldimethylphosphanylium)-1-phosphonoethyl]phosphonate |
Type | Small organic molecule |
Emp. Form. | C16H37O6P3 |
Mol. Mass. | 418.3827 |
SMILES | CCCCCCCCCCCC[P+](C)(C)CC(P(O)(O)=O)P(O)([O-])=O |
Structure |
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