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TargetDimer of Gag-Pol polyprotein [501-599]
LigandBDBM608734
Substrate/CompetitorFluorescent peptide substrate
Meas. Tech.Protease Inhibition Assay
pH5.5±n/a
Temperature310.15±n/a K
Ki 0.24±n/a nM
Citation Lam, PYRu, YJadhav, PKAldrich, PEDeLucca, GVEyermann, CJChang, CHEmmett, GHoller, ERDaneker, WFLi, LConfalone, PNMcHugh, RJHan, QLi, RMarkwalder, JASeitz, SPSharpe, TRBacheler, LTRayner, MMKlabe, RMShum, LWinslow, DLKornhauser, DMHodge, CN Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas. J Med Chem39:3514-25 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [501-599]
Name:Dimer of Gag-Pol polyprotein [501-599]
Synonyms:HIV-1 Protease | HIV-1 Protease, recombinant, isolate HXB2
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [501-599]
Synonyms:BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10795.19
Organism:Human immunodeficiency virus type 1
Description:P03367[501-599]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [501-599]
Synonyms:BRU isolated | HIV-1 Protease B Subtype Chain A | HIV-1 Protease B Subtype Chain B | HIV-1 Protease chain A | LAI(Wild type) | POL_HV1BR | Protease Retropepsin | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10795.19
Organism:Human immunodeficiency virus type 1
Description:P03367[501-599]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM608734
Fluorescent peptide substrate
Name:Fluorescent peptide substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:4608.75
Organism:n/a
Description:n/a
Residue:42
Sequence:
2-aminobenzoyl-Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-
Ala