Reaction Details |
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Target | ATP phosphoribosyltransferase |
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Ligand | BDBM25314 |
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Substrate/Competitor | BDBM25315 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 8.5±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 4000±n/a nM |
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Comments | 76% inhibition @ 10 uM. |
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Citation | Cho, Y; Ioerger, TR; Sacchettini, JC Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem51:5984-92 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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ATP phosphoribosyltransferase |
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Name: | ATP phosphoribosyltransferase |
Synonyms: | ATP-PRT | ATP-PRTase | HIS1_MYCTU | hisG |
Type: | Glycosyltransferase |
Mol. Mass.: | 30473.85 |
Organism: | Mycobacterium tuberculosis |
Description: | n/a |
Residue: | 284 |
Sequence: | MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSG
ELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLV
RKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAV
LIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIA
PLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
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BDBM25314 |
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BDBM25315 |
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Name | BDBM25314 |
Synonyms: | 2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide | ChemBridge 1,2,4-triazine, 4 |
Type | Small organic molecule |
Emp. Form. | C20H15N5OS2 |
Mol. Mass. | 405.496 |
SMILES | O=C(CSc1nnc(-c2ccccc2)c(n1)-c1ccccc1)Nc1nccs1 |
Structure |
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