| Reaction Details |
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 | Report a problem with these data |
| Target | ATP phosphoribosyltransferase |
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| Ligand | BDBM25317 |
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| Substrate/Competitor | BDBM25315 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 8.5±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 10000±n/a nM |
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| Comments | 50% inhibition @ 10 uM. |
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| Citation |  Cho, Y; Ioerger, TR; Sacchettini, JC Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem51:5984-92 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| |
| ATP phosphoribosyltransferase |
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| Name: | ATP phosphoribosyltransferase |
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| Synonyms: | ATP-PRT | ATP-PRTase | HIS1_MYCTU | hisG |
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| Type: | Glycosyltransferase |
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| Mol. Mass.: | 30473.85 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 284 |
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| Sequence: | MLRVAVPNKGALSEPATEILAEAGYRRRTDSKDLTVIDPVNNVEFFFLRPKDIAIYVGSG
ELDFGITGRDLVCDSGAQVRERLALGFGSSSFRYAAPAGRNWTTADLAGMRIATAYPNLV
RKDLATKGIEATVIRLDGAVEISVQLGVADAIADVVGSGRTLSQHDLVAFGEPLCDSEAV
LIERAGTDGQDQTEARDQLVARVQGVVFGQQYLMLDYDCPRSALKKATAITPGLESPTIA
PLADPDWVAIRALVPRRDVNGIMDELAAIGAKAILASDIRFCRF
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| BDBM25317 |
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| BDBM25315 |
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| Name | BDBM25317 |
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| Synonyms: | 3-hydroxy-4-[(E)-2-(1-hydroxynaphthalen-2-yl)diazen-1-yl]-7-nitronaphthalene-1-sulfonic acid | ChemBridge nitronaphthalene-1-sulfonic acid, 14 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H13N3O7S |
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| Mol. Mass. | 439.398 |
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| SMILES | Oc1cc(c2cc(ccc2c1N=Nc1ccc2ccccc2c1O)[N+]([O-])=O)S(O)(=O)=O |w:12.14| |
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| Structure | 
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