Reaction Details |
| Report a problem with these data |
Target | Enoyl-ACP reductase |
---|
Ligand | BDBM8726 |
---|
Substrate/Competitor | BDBM8737 |
---|
Meas. Tech. | PfENR Enzymatic Inhibition Assay |
---|
pH | 7.9±n/a |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 73±21 nM |
---|
Citation | Freundlich, JS; Wang, F; Tsai, HC; Kuo, M; Shieh, HM; Anderson, JW; Nkrumah, LJ; Valderramos, JC; Yu, M; Kumar, TR; Valderramos, SG; Jacobs, WR; Schiehser, GA; Jacobus, DP; Fidock, DA; Sacchettini, JC X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. J Biol Chem282:25436-44 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Enoyl-ACP reductase |
---|
Name: | Enoyl-ACP reductase |
Synonyms: | Enoyl-ACP Reductase (PfENR) | Enoyl-ACP reductase |
Type: | Enzyme |
Mol. Mass.: | 49844.02 |
Organism: | Plasmodium falciparum |
Description: | Q9BJJ9 |
Residue: | 432 |
Sequence: | MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNK
MKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELS
KRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEE
TKNNKRYNMLQNYTIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSK
SSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLG
RNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNRHDVHNIMNNSGEKEEKKI
SASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIM
FLPDDIYRNENE
|
|
|
BDBM8726 |
---|
BDBM8737 |
---|
Name | BDBM8726 |
Synonyms: | 5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35 |
Type | Small organic molecule |
Emp. Form. | C12H7Cl3O2 |
Mol. Mass. | 289.542 |
SMILES | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
Structure |
|