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TargetDimer of Gag-Pol polyprotein [489-587]
LigandBDBM192
Substrate/Competitorfluorogenic peptide substrate
Meas. Tech.Protease Inhibition Assay
pH4.7±n/a
Temperature303.15±n/a K
Ki 0.07±n/a nM
Comments
Citation Sham, HLZhao, CStewart, KDBetebenner, DALin, SPark, CHKong, XPRosenbrook, WHerrin, TMadigan, DVasavanonda, SLyons, NMolla, ASaldivar, AMarsh, KCMcDonald, EWideburg, NEDenissen, JFRobins, TKempf, DJPlattner, JJNorbeck, DW A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease. J Med Chem39:392-7 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587]
Name:Dimer of Gag-Pol polyprotein [489-587]
Synonyms:HIV-1 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM192
fluorogenic peptide substrate
Name:fluorogenic peptide substrate
Synonyms:n/a
Type:fluorogenic peptide
Mol. Mass.:3550.86
Organism:n/a
Description:n/a
Residue:33
Sequence:
DABCYL-GABASer-Gln-Tyr-Pro-Ile-Val-Gln-EDANS