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TargetSerine/threonine-protein kinase PLK1
LigandBDBM25501
Substrate/CompetitorCdc25C Substrate Peptide
Meas. Tech.Plk in Vitro Assay
pH7.2±n/a
Temperature303.15±n/a K
IC50 7685±n/a nM
Citation Fucini, RVHanan, EJRomanowski, MJElling, RALew, WBarr, KJZhu, JYoburn, JCLiu, YFahr, BTFan, JLu, YPham, PChoong, ICVanderPorten, ECBui, MPurkey, HEEvanchik, MJYang, W Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg Med Chem Lett18:5648-52 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase PLK1
Name:Serine/threonine-protein kinase PLK1
Synonyms:PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:Serine/threonine-protein kinase
Mol. Mass.:68277.16
Organism:Homo sapiens (Human)
Description:P53350
Residue:603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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  Blast E-value cutoff:
BDBM25501
Cdc25C Substrate Peptide
Name:Cdc25C Substrate Peptide
Synonyms:5-carboxamido-fluorescein (5FAM) labeled peptide
Type:Fluorophore tagged peptide
Mol. Mass.:2066.83
Organism:n/a
Description:n/a
Residue:18
Sequence:
5FAM-RALMEASFADQAR-NH2