| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C theta type |
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| Ligand | BDBM25558 |
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| Substrate/Competitor | PKC Peptide Substrate |
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| Meas. Tech. | PKC theta IMAP Kinase Assay |
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| pH | 7.2±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 79±4 nM |
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| IC50 | 70±30 nM |
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| Citation |  Cole, DC; Asselin, M; Brennan, A; Czerwinski, R; Ellingboe, JW; Fitz, L; Greco, R; Huang, X; Joseph-McCarthy, D; Kelly, MF; Kirisits, M; Lee, J; Li, Y; Morgan, P; Stock, JR; Tsao, DH; Wissner, A; Yang, X; Chaudhary, D Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. J Med Chem51:5958-63 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein kinase C theta type |
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| Name: | Protein kinase C theta type |
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| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 81878.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
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| Residue: | 706 |
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| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
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| BDBM25558 |
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| PKC Peptide Substrate |
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| Name: | PKC Peptide Substrate |
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| Synonyms: | n/a |
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| Type: | Fluorescent peptide |
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| Mol. Mass.: | 2051.95 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 17 |
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| Sequence: | |
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