Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase B-raf |
---|
Ligand | BDBM25617 |
---|
Substrate/Competitor | biotin-MEK |
---|
Meas. Tech. | In Vitro BRAF Kinase Assay |
---|
pH | 7±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 160±n/a nM |
---|
Citation | Tsai, J; Lee, JT; Wang, W; Zhang, J; Cho, H; Mamo, S; Bremer, R; Gillette, S; Kong, J; Haass, NK; Sproesser, K; Li, L; Smalley, KS; Fong, D; Zhu, YL; Marimuthu, A; Nguyen, H; Lam, B; Liu, J; Cheung, I; Rice, J; Suzuki, Y; Luu, C; Settachatgul, C; Shellooe, R; Cantwell, J; Kim, SH; Schlessinger, J; Zhang, KY; West, BL; Powell, B; Habets, G; Zhang, C; Ibrahim, PN; Hirth, P; Artis, DR; Herlyn, M; Bollag, G Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A105:3041-6 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Serine/threonine-protein kinase B-raf |
---|
Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
|
|
|
BDBM25617 |
---|
biotin-MEK |
---|
Name: | biotin-MEK |
Synonyms: | n/a |
Type: | biotinylated substrate |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | Perkin-Elmer s AlphaScreen assay kit. |
Residue: | 3 |
Sequence: | |