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TargetTyrosine-protein kinase FRK
LigandBDBM25617
Substrate/CompetitorSubstrate Peptide Tyr 01
Meas. Tech.Z-LYTE Enzymatic Kinase Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 1300±n/a nM
Citation Tsai, J; Lee, JT; Wang, W; Zhang, J; Cho, H; Mamo, S; Bremer, R; Gillette, S; Kong, J; Haass, NK; Sproesser, K; Li, L; Smalley, KS; Fong, D; Zhu, YL; Marimuthu, A; Nguyen, H; Lam, B; Liu, J; Cheung, I; Rice, J; Suzuki, Y; Luu, C; Settachatgul, C; Shellooe, R; Cantwell, J; Kim, SH; Schlessinger, J; Zhang, KY; West, BL; Powell, B; Habets, G; Zhang, C; Ibrahim, PN; Hirth, P; Artis, DR; Herlyn, M; Bollag, G Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A105:3041-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Tyrosine-protein kinase FRK
Name:Tyrosine-protein kinase FRK
Synonyms:FRK | FRK_HUMAN | FYN-related kinase | Nuclear tyrosine protein kinase RAK | PTK5 | RAK | SRC | Tyrosine Kinase FRK
Type:Tyrosine-protein kinase
Mol. Mass.:58254.41
Organism:Homo sapiens (Human)
Description:P42685
Residue:505
Sequence:
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAED
LSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGA
IGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRR
RIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRL
GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLED
PIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNV
LVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFG
ILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTF
ETLRWKLEDYFETDSSYSDANNFIR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM25617
Substrate Peptide Tyr 01
Name:Substrate Peptide Tyr 01
Synonyms:n/a
Type:Peptide
Mol. Mass.:358.43
Organism:n/a
Description:Z -LYTE biochemical assay kit (SelectScreen; Invitrogen).
Residue:3
Sequence:
n/a