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TargetDimer of Gag-Pol polyprotein [489-587]
LigandBDBM210
Substrate/CompetitorHIV Protease peptide substrate
Meas. Tech.Protease Inhibition Assay
pH6±n/a
Temperature310.15±n/a K
IC50 150±n/a nM
CommentsIC50 value had to be determined at suboptimal conditions at pH 6 in order to ensure solubility of inhibitors with different physicochemical properties.
Citation Fassler, ABold, GCapraro, HGCozens, RMestan, JPoncioni, BRosel, JTintelnot-Blomley, MLang, M Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability. J Med Chem39:3203-16 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dimer of Gag-Pol polyprotein [489-587]
Name:Dimer of Gag-Pol polyprotein [489-587]
Synonyms:HIV-1 Protease
Type:Protein Complex
Mol. Mass.:n/a
Description:n/a
Components:This complex has 2 components.
Component 1
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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Component 2
Name:Gag-Pol polyprotein [489-587]
Synonyms:HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:Enzyme Subunit
Mol. Mass.:10822.21
Organism:Human immunodeficiency virus type 1
Description:P12497[489-587]
Residue:99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM210
HIV Protease peptide substrate
Name:HIV Protease peptide substrate
Synonyms:n/a
Type:peptide
Mol. Mass.:2417.69
Organism:synthesized
Description:n/a
Residue:20
Sequence:
RRSNQ VSQNY PIVQN IQGRR
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