Reaction Details |
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Target | Calpain-1 catalytic subunit |
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Ligand | BDBM25886 |
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Substrate/Competitor | BODIPY FL casein |
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Meas. Tech. | BODIPY Fluorescent Microplate Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 790±n/a nM |
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Citation | Jones, MA; Morton, JD; Coxon, JM; McNabb, SB; Lee, HY; Aitken, SG; Mehrtens, JM; Robertson, LJ; Neffe, AT; Miyamoto, S; Bickerstaffe, R; Gately, K; Wood, JM; Abell, AD Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem16:6911-23 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Calpain-1 catalytic subunit |
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Name: | Calpain-1 catalytic subunit |
Synonyms: | Calpain I 80 kDa subunit | Calpain-1 | o-CAPN1 |
Type: | Enzyme |
Mol. Mass.: | 82073.19 |
Organism: | Ovis aries (sheep) |
Description: | B2ZA85 |
Residue: | 716 |
Sequence: | MAEEFITPVYCTGVSAQVQKQRAKELGLGRHENAIKYLGQDYEQLRVHCLQRGALFRDEA
FPPVPQSLGFKELGPNSSKTYGIKWKRPTELFSNPQFIVDGATRTDICQGALGACWLLAA
IASLTLNDTLLHRVVPHGQSFQDGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYNIILK
ALERGSLLGCSIDISSILDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYVREQLRIKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
QRFRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPDPDDYGGRESGCS
FLLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFI
NLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTQELDDQVQANLPDEQVL
SEEEIDENFKSLFRQLAGEDMEISVKELRTILNRIISKHKDLRTTGFSVESCRSMVNLMD
RDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIEFAGFKLNKKLYEL
IITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM25886 |
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BODIPY FL casein |
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Name: | BODIPY FL casein |
Synonyms: | 4,4-difluoro-5,7-dimethyl-4-bora-3a,4adiaza-s-indacene-3-propionic acid (BODIPY-FL) labeled casein |
Type: | fluorescent dye-labeled substrate |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | n/a |
Residue: | 3 |
Sequence: | |