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TargetCalpain-1 catalytic subunit
LigandBDBM25886
Substrate/CompetitorBODIPY FL casein
Meas. Tech.BODIPY Fluorescent Microplate Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 790±n/a nM
Citation Jones, MAMorton, JDCoxon, JMMcNabb, SBLee, HYAitken, SGMehrtens, JMRobertson, LJNeffe, ATMiyamoto, SBickerstaffe, RGately, KWood, JMAbell, AD Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors. Bioorg Med Chem16:6911-23 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Calpain-1 catalytic subunit
Name:Calpain-1 catalytic subunit
Synonyms:Calpain I 80 kDa subunit | Calpain-1 | o-CAPN1
Type:Enzyme
Mol. Mass.:82073.19
Organism:Ovis aries (sheep)
Description:B2ZA85
Residue:716
Sequence:
MAEEFITPVYCTGVSAQVQKQRAKELGLGRHENAIKYLGQDYEQLRVHCLQRGALFRDEA
FPPVPQSLGFKELGPNSSKTYGIKWKRPTELFSNPQFIVDGATRTDICQGALGACWLLAA
IASLTLNDTLLHRVVPHGQSFQDGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYNIILK
ALERGSLLGCSIDISSILDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYVREQLRIKMEDGEFWMSFRDFMREFTRLEICNLTPDALKS
QRFRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPDPDDYGGRESGCS
FLLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFI
NLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTQELDDQVQANLPDEQVL
SEEEIDENFKSLFRQLAGEDMEISVKELRTILNRIISKHKDLRTTGFSVESCRSMVNLMD
RDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIEFAGFKLNKKLYEL
IITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM25886
BODIPY FL casein
Name:BODIPY FL casein
Synonyms:4,4-difluoro-5,7-dimethyl-4-bora-3a,4adiaza-s-indacene-3-propionic acid (BODIPY-FL) labeled casein
Type:fluorescent dye-labeled substrate
Mol. Mass.:358.43
Organism:n/a
Description:n/a
Residue:3
Sequence:
n/a