Reaction Details |
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Target | Carbonic anhydrase 14 |
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Ligand | BDBM25896 |
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Substrate/Competitor | BDBM10856 |
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Meas. Tech. | CA Inhibition Assay |
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Ki | 13±n/a nM |
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Citation | Temperini, C; Innocenti, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies. Bioorg Med Chem Lett18:4282-6 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Carbonic anhydrase 14 |
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Name: | Carbonic anhydrase 14 |
Synonyms: | CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV) |
Type: | Enzyme |
Mol. Mass.: | 37665.67 |
Organism: | Homo sapiens (Human) |
Description: | Human (cloned) isozyme. |
Residue: | 337 |
Sequence: | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
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BDBM25896 |
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BDBM10856 |
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Name | BDBM25896 |
Synonyms: | EMD 486019 | [2-(cycloheptylmethyl)-1,1-dioxo--benzothiophen-6-yl] sulfamate |
Type | Small organic molecule |
Emp. Form. | C16H21NO5S2 |
Mol. Mass. | 371.472 |
SMILES | NS(=O)(=O)Oc1ccc2C=C(CC3CCCCCC3)S(=O)(=O)c2c1 |t:9| |
Structure |
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