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TargetCarbonic anhydrase 4
LigandBDBM25903
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 303±n/a nM
Citation Temperini CCecchi AScozzafava ASupuran CT Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg Med Chem Lett 18:2567-73 (2008) [PubMed]  Article
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Carbonic anhydrase 4
Name:Carbonic anhydrase
Synonyms:CA-IV | Carbonate dehydratase IV | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:Enzyme
Mol. Mass.:35037.98
Organism:Homo sapiens (Human)
Description:P22748
Residue:312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
PMLACLLAGFLR
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  Blast E-value cutoff:
BDBM25903
BDBM10856
NameBDBM25903
Synonyms:3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid | Bumetanide | Bumex | Burinex | Fordiuran | cid_2471
TypeSmall organic molecule
Emp. Form.C17H20N2O5S
Mol. Mass.364.416
SMILESCCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O
Structure
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