| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 14 |
|---|
| Ligand | BDBM10886 |
|---|
| Substrate/Competitor | BDBM10856 |
|---|
| Meas. Tech. | CA Inhibition Assay |
|---|
| Ki | 33±n/a nM |
|---|
| Citation |  Temperini, C; Cecchi, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg Med Chem Lett18:2567-73 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase 14 |
|---|
| Name: | Carbonic anhydrase 14 |
|---|
| Synonyms: | CA-XIV | CA14 | CAH14_HUMAN | Carbonate dehydratase XIV | Carbonic Anhydrase XIV | Carbonic anhydrase | Carbonic anhydrase 14 | Carbonic anhydrase 14 (CA XIV) | Carbonic anhydrase XIV (CA XIV) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 37665.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human (cloned) isozyme. |
|---|
| Residue: | 337 |
|---|
| Sequence: | MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD
LPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGG
SEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSH
LHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQ
LEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVG
CLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
|
|
|
|---|
| BDBM10886 |
|---|
| BDBM10856 |
|---|
| Name | BDBM10886 |
|---|
| Synonyms: | 2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide | BZA1 | Benzolamide | Benzolamide (BZA) | CHEMBL73962 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C8H8N4O4S3 |
|---|
| Mol. Mass. | 320.369 |
|---|
| SMILES | NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
