Reaction Details |
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Target | Tyrosine-protein kinase ITK/TSK |
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Ligand | BDBM384534 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Activity In Vitro Assays |
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IC50 | 0.600±n/a nM |
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Citation | Owens, T; Hill, RJ Benzimidazole derivatives as RLK and ITK inhibitors US Patent US9932329 Publication Date 4/3/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase ITK/TSK |
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Name: | Tyrosine-protein kinase ITK/TSK |
Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
Type: | Protein |
Mol. Mass.: | 71839.20 |
Organism: | Homo sapiens (Human) |
Description: | Q08881 |
Residue: | 620 |
Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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BDBM384534 |
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n/a |
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Name | BDBM384534 |
Synonyms: | N-(1-(((R)-1-(2-cyano-4,4-dimethylpent-2-enoyl)pyrrolidin-2-yl)methyl)-5-((((R)-1-hydroxy-3,3-dimethylbutan-2-yl)amino)methyl)-1H-benzo[d]imidazol-2-yl)-5-(oxazol-5-yl)-thiophene-2-carboxamide formate | US9932329, Cpd # 4 |
Type | Small organic molecule |
Emp. Form. | C35H43N7O4S |
Mol. Mass. | 657.825 |
SMILES | CC(C)(C)C=C(C#N)C(=O)N1CCC[C@@H]1Cn1c(NC(=O)c2ccc(s2)-c2cnco2)nc2cc(CN[C@@H](CO)C(C)(C)C)ccc12 |r,w:4.3| |
Structure |
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