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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Carbonic anhydrase 3 | ||
| Ligand | BDBM25918 | ||
| Substrate/Competitor | BDBM10856 | ||
| Meas. Tech. | CA Inhibition Assay | ||
| Ki | 5400000±n/a nM | ||
| Citation |  Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem16:9113-20 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Carbonic anhydrase 3 | |||
| Name: | Carbonic anhydrase 3 | ||
| Synonyms: | CA-III | CA3 | CAH3_HUMAN | Carbonate dehydratase III | Carbonic Anhydrase III | Carbonic anhydrase | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 29562.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human cloned isozyme. | ||
| Residue: | 260 | ||
| Sequence: |
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| BDBM25918 | |||
| BDBM10856 | |||
| Name | BDBM25918 | ||
| Synonyms: | 2-(hydrazinecarbonyl)-3-(2,3,4,5,6-pentafluorophenyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2n | indole sulfonamide, 8n | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H9F5N4O3S | ||
| Mol. Mass. | 420.314 | ||
| SMILES | NNC(=O)c1[nH]c2ccc(cc2c1-c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O |(3.94,3.73,;2.61,4.5,;1.28,3.73,;2.05,2.4,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-1.17,4.98,;-.69,6.44,;-1.8,7.52,;-3.28,7.1,;-1.42,9.01,;-2.52,10.08,;.06,9.43,;.44,10.92,;1.17,8.36,;2.65,8.78,;.79,6.86,;1.89,5.79,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,)| | ||
| Structure | 
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