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TargetCarbonic anhydrase 7
LigandBDBM25911
Substrate/CompetitorBDBM10856
Meas. Tech.CA Inhibition Assay
Ki 82±n/a nM
Citation Güzel, OInnocenti, AScozzafava, ASalman, AParkkila, SHilvo, MSupuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem16:9113-20 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carbonic anhydrase 7
Name:Carbonic anhydrase 7
Synonyms:CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:Enzyme
Mol. Mass.:29664.11
Organism:Homo sapiens (Human)
Description:Human cloned isozyme.
Residue:264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA
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  Blast E-value cutoff:
BDBM25911
BDBM10856
NameBDBM25911
Synonyms:3-(2-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2g | indole sulfonamide, 8g
TypeSmall organic molecule
Emp. Form.C15H13ClN4O3S
Mol. Mass.364.807
SMILESNNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Cl)S(N)(=O)=O |(3.59,5.07,;2.05,5.07,;1.28,3.73,;2.05,2.4,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-1.17,4.98,;-.69,6.44,;.79,6.86,;1.17,8.36,;.06,9.43,;-1.42,9.01,;-1.8,7.52,;-3.28,7.1,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,)|
Structure
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