Reaction Details | |||
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Target | Carbonic anhydrase 12 | ||
Ligand | BDBM25914 | ||
Substrate/Competitor | BDBM10856 | ||
Meas. Tech. | CA Inhibition Assay | ||
Ki | 77±n/a nM | ||
Citation | Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem16:9113-20 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Carbonic anhydrase 12 | |||
Name: | Carbonic anhydrase 12 | ||
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 | ||
Type: | Enzyme | ||
Mol. Mass.: | 39456.00 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Catalytic domain of human cloned isozyme was used in the assay | ||
Residue: | 354 | ||
Sequence: |
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BDBM25914 | |||
BDBM10856 | |||
Name | BDBM25914 | ||
Synonyms: | 3-(2-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2j | indole sulfonamide, 8j | ||
Type | Small organic molecule | ||
Emp. Form. | C15H13BrN4O3S | ||
Mol. Mass. | 409.258 | ||
SMILES | NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Br)S(N)(=O)=O |(3.59,5.07,;2.05,5.07,;1.28,3.73,;2.05,2.4,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-1.17,4.98,;-.69,6.44,;.79,6.86,;1.17,8.36,;.06,9.43,;-1.42,9.01,;-1.8,7.52,;-3.28,7.1,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,)| | ||
Structure |