Ki Summary

Reaction Details

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Target

Carbonic anhydrase 15 [19-324]

Ligand

BDBM25918

Substrate/Competitor

BDBM10856

Meas. Tech.

CA Inhibition Assay

48±n/a nM

Citation

Güzel, O; Innocenti, A; Scozzafava, A; Salman, A; Parkkila, S; Hilvo, M; Supuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem16:9113-20 (2008) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Carbonic anhydrase 15 [19-324]

Name:

Carbonic anhydrase 15 [19-324]

Synonyms:

Type:

Enzyme

Mol. Mass.:

33409.51

Organism:

Mus musculus (mouse)

Description:

Mouse cloned isozyme.

Residue:

306

Sequence:

VDSSGTWCYDSQDPKCGPAHWKELAPACGGPTQSPINIDLRLVQRDYTLKPFIFQGYDSA
PQDPWVLENDGHTVLLRVNSCQQNCPAIRGAGLPSPEYRLLQLHFHWGSPGHQGSEHSLD
EKHGSMEMHMVHMNTKYQSMEDARSQPDGFAILAVLLVEEDRDNTNFSAIVSGLKNLSSP
GVAVNLTSTFALASLLPSALRLLRYYRYSGSLTTPGCEPAVLWTVFENTVPIGHAQVVQF
QAVLQTGPPGLHPRPLTSNFRPQQPLGGRRISASPEASVRSSVSTLPCLHLALVGLGVGL
RLWQGP

BDBM25918

BDBM10856

Name

BDBM25918

Synonyms:

2-(hydrazinecarbonyl)-3-(2,3,4,5,6-pentafluorophenyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2n | indole sulfonamide, 8n

Type

Small organic molecule

Emp. Form.

C15H9F5N4O3S

Mol. Mass.

420.314

SMILES

NNC(=O)c1[nH]c2ccc(cc2c1-c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O |(3.94,3.73,;2.61,4.5,;1.28,3.73,;2.05,2.4,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-1.17,4.98,;-.69,6.44,;-1.8,7.52,;-3.28,7.1,;-1.42,9.01,;-2.52,10.08,;.06,9.43,;.44,10.92,;1.17,8.36,;2.65,8.78,;.79,6.86,;1.89,5.79,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,)|

Structure