Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCaspase-1
LigandBDBM224
Substrate/CompetitorCaspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Meas. Tech.Fluorometric Assay
pH7.4±n/a
Temperature298.15±n/a K
Ki 8300±n/a nM
Citation Choong, ICLew, WLee, DPham, PBurdett, MTLam, JWWiesmann, CLuong, TNFahr, BDeLano, WLMcDowell, RSAllen, DAErlanson, DAGordon, EMO'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Caspase-1
Name:Caspase-1
Synonyms:CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:Enzyme
Mol. Mass.:45154.13
Organism:Homo sapiens (Human)
Description:P29466
Residue:404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM224
Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Name:Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
Synonyms:Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC | Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC
Type:Peptide
Mol. Mass.:584.05
Organism:n/a
Description:Molecular Mass of WEHD
Residue:4
Sequence:
WEHD