Reaction Details |
| Report a problem with these data |
Target | Caspase-1 |
---|
Ligand | BDBM224 |
---|
Substrate/Competitor | Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
---|
Meas. Tech. | Fluorometric Assay |
---|
pH | 7.4±n/a |
---|
Temperature | 298.15±n/a K |
---|
Ki | 8300±n/a nM |
---|
Citation | Choong, IC; Lew, W; Lee, D; Pham, P; Burdett, MT; Lam, JW; Wiesmann, C; Luong, TN; Fahr, B; DeLano, WL; McDowell, RS; Allen, DA; Erlanson, DA; Gordon, EM; O'Brien, T Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem45:5005-22 (2002) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Caspase-1 |
---|
Name: | Caspase-1 |
Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
Type: | Enzyme |
Mol. Mass.: | 45154.13 |
Organism: | Homo sapiens (Human) |
Description: | P29466 |
Residue: | 404 |
Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
BDBM224 |
---|
Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
---|
Name: | Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC |
Synonyms: | Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC | Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC |
Type: | Peptide |
Mol. Mass.: | 584.05 |
Organism: | n/a |
Description: | Molecular Mass of WEHD |
Residue: | 4 |
Sequence: | |